Where will post-COVID molecular diagnostics go next? And how can it get there quicker?

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The Challenge:
The pandemic certainly didn’t invent in-vitro diagnostics, but thought leaders in this medical technology space now recognize how COVID revealed both the potential and challenges inherent in scaling molecular diagnostics.
No matter which disease process clinical interventions based on in vitro diagnostics are aimed at – infectious agents, diabetes, cancer, biomarkers for brain, heart or other organ pathologies, etc. – there is a marked advantage of patient-friendly test methods that use easily collected samples such as saliva, exhalations, or pin prick blood samples. Often though, the quantity of genetic material culled by these sampling techniques is minute. This is the same challenge that researchers faced when studying COVID and immunity.

PCR (Polymerase Chain Reaction) testing – a method developed in the late 20th Century for copying and in effect amplifying very small segments of genetic material – is at the heart of the COVID testing that is now ubiquitous. PCR testing’s ability to do the equivalent of multiplying a minute sample many times over is projected to be the cornerstone of nearly all molecular diagnostic methods in the coming years. In fact, it already is at the heart of most immunodiagnostic and molecular assay tests in clinical laboratories worldwide today. From an engineering standpoint, the integrity of PCR testing requires microscale leak testing to the most stringent standards (e.g. detecting leaks as small as 0.008 sccm, 8 microliters per minute, equivalent to a 0.5 micron hole). Consider also the challenge of then scaling successful molecular diagnostics just as COVID testing has required. If one has not grappled with the challenges of scaling such solutions – and doing so rapidly – this task can appear daunting.

InterTech Solution:
Helping the medical technology innovators that scaled rapid COVID testing is exactly how InterTech has assisted in the taming of the pandemic-creating leak test solutions used in rapid testing systems. These PCR testing solutions were made possible and scalable with InterTech MicroScale Testing Technology to achieve the 8 microliters per minute standard with high repeatability and reliability.

These turnkey microleak testing solutions – for both in-line testing and audit testing – have at their core InterTech’s unsurpassed proprietary test technologies – superior mass flow test sensors, pressure decay test sensor designs, and unique test fixtures.
InterTech continues to partner with global leaders in in vitro diagnostics and molecular assays requiring leak-proof testing components and assured closed container integrity.

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InterTech Design Report (DR-177)

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Headache-free Testing – and FAST!

The Challenge: Trying to make do with a less skilled workforce? Facing demands for faster deliveries despite supply chain issues? Need dramatic throughput gains to counter inflationary pressures? All this – yet, quality cannot be compromised!!!
Manufacturers of a wide range of products requiring error-free leak and functional testing – medical devices, electronics packaging, pharmaceutical delivery devices, automotive and more – are facing an unprecedented demand to develop smarter ways of managing the real-world pressures of our post-pandemic world. There is far less room for bottlenecks and production drags on manufacture and testing. It’s time to get smarter about testing!

The InterTech Solution: InterTech’s test engineering talent – which has created more patented solutions for best-in-class test technology than any other company in the world – is partnering with leading global manufacturers of test-intensive products to help them work faster and smarter – not harder.  No-cost consultations with InterTech’s Test Engineering Team – in-person or by video consult – can determine which of the family of InterTech Smart Testing Solutions are best matches for your testing challenges.
Some of the InterTech Smart Testing Solutions with potential to significantly impact your bottom line includes: InterTech Universal Leak Tester, Leantest, Ex-Heat, Gauge R&R mode, InterTech Patented Mass Flow Sensors, and Ethernet IP and Webpage Enabled.

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InterTech Design Report (DR-176)

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Ensuring Your Fuel Filtration System Is On Par With Today’s Engines

The Challenge: Today’s diesel engines and related engine parts must maintain the high-performance levels that both laws and the market require. Common rail fuel injectors, for example, operate at increasingly higher pressures, today up to 2,000-3,100 bar/ 30,000-45, 000 psi. At the same time, emissions regulations are more stringent than ever before, and if anything, will become more demanding in the coming years. These diesel engine considerations – for smooth operation and emission controls – require clean fuel, and the highly functional fuel filter technology that ensures it. If fuel filters are not on par with engine systems, clean fuel becomes elusive. In turn, that means expensive repairs and unplanned downtime for engines, fuel injectors and fuel pumps. Oil and fuel filter designs are continuously improving. Perfecting functional, leak and other tests to ensure both the integrity of filters, as well as optimal testing efficiencies during production, requires a deep bench of test engineering expertise steeped in the nuances of how these related parts – engines, fuel injectors, fuel pumps, and fuel and oil filters work.

The InterTech Solution: InterTech Development Company has been the source of choice for the A-list of global diesel engine and fuel filter innovators for decades. This work has included both partnering with diesel engine and oil and fuel filter design engineers developing prototypes, as well as manufacturing engineers seeking production line efficiencies.

Read Design Report DR-176